This study analyses the role of local entrepreneurship in social development in São Tomé and Príncipe, focusing on how entrepreneurs can contribute to the Sustainable Development Goals (SDGs). The research was based on field research, conducted through a structured questionnaire applied to 100 entrepreneurs, selected representatively based on the latest national census. The instrument included closed questions on the main social indicators of the SDGs, allowing comparisons between the entrepreneurial population and the general population. The questions were adapted to the local context, considering educational and linguistic limitations, and validated with São Tomé nationals. The results show that entrepreneurs drive progress in the SDGs, exceeding the population average in 15 of the 24 indicators analysed. The study highlights how entrepreneurial ecosystems can be better leveraged to promote sustainable development and social inclusion.